Active Clinical Trials
25 clinical trials currently in progress for PKD — including drug candidates, metabolic interventions, and lifestyle studies.
Drug Trials (16)
Pharmaceutical compounds in clinical trials for PKD
ABBV-CLS-628
Calico Life Sciences / AbbVie • Phase 2 • ANCHOR
Atorvastatin
Taipei Medical University Shuang Ho Hospital • Phase 2 • Atorvastatin + Sodium Bicarbonate Pilot
AZD1613
AstraZeneca • Phase 1 • PIONEER-PKD
Bempedoic Acid
University of Vermont (DoD-funded) • Phase 2 • BEAT-PKD
Dapagliflozin
University of Cologne • Phase 3 • STOP-PKD
Empagliflozin
Multiple Sponsors • Phase 2 • EMPA-PKD / SIDIA / Colorado Feasibility
Farabursen (CYX082)
Novartis (acquired Regulus Therapeutics) • Phase 3 • Phase 3 Registrational Trial
GSK4771261
GlaxoSmithKline • Phase 1 • Phase 1a/1b Single Ascending Dose
Hydrochlorothiazide
University Medical Center Groningen • Phase 3 • HYDRO-PROTECT
JMKX003142
Jemincare • Phase 2 • Phase 2 ADPKD
Metformin
University of Queensland • Phase 3 • IMPEDE-PKD
PYC-003
PYC Therapeutics • Phase 1 • First-in-Human PKD1
Rotigotine
University Hospital Rouen • Phase 2 • ETERNAL-PKD
Tamibarotene
Rege Nephro Co., Ltd. • Phase 2 • Phase 2a ADPKD
Tirzepatide
University of Colorado Denver • Phase 2 • Tirzepatide in Overweight ADPKD
VX-407
Vertex Pharmaceuticals • Phase 2 • AGLOW
Therapy & Lifestyle Trials (5)
Non-drug interventional studies for PKD
Ketogenic Diet (52-week)
Ohio State University (DoD-funded) • Well-Formulated Keto Diet for PKD
Ketogenic Metabolic Therapy (Juntendo)
Juntendo University, Tokyo • Juntendo KetoCitra + Ren-Nu Trial
Ren-Nu + KetoCitra (Cleveland Clinic)
Cleveland Clinic • PKD-KETO
Exogenous Ketone Supplement (RCT)
Gødstrup Hospital, Denmark • Effects of Exogenous Ketosis on Proteinuria and Renal Function
Metformin
University of Queensland • IMPEDE-PKD (Phase 3)
Metabolic Intervention Trials (4)
Ketogenic and metabolic studies with ongoing enrollment or interim results
Juntendo University 12-Month Interim Results
Juntendo University, Tokyo • Shigeo Horie
Juntendo University 3-Month Interim Results
Juntendo University, Tokyo • Shigeo Horie
Cleveland Clinic KetoCitra Trial
Cleveland Clinic, Ohio • Richard A. Fatica
Ohio State Well-Formulated Ketogenic Diet Trial
Ohio State University Wexner Medical Center • Jeff Volek